Pyruvate dehydrogenase kinase 4 (PDK4) is a regulator of PDH, as it inhibits PDH activity, which in turn will increase the influx of acetyl-coA from beta-oxidation into the TCA cycle, thereby leading to enhanced FA oxidation and slowing of glycolysis or glycolytic intermediates to alternative metabolic pathways.
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Jul 07, 2010 · Pyruvate oxidation occurs in the inner membrane of the mitochondria. This process is a source of acetyl-CoA molecules for the citric acid cycle. - - - - - - - - - - - - - - Pyruvate oxidation occurs in three easy steps. - First, the pyruvate is oxidized (it goes from 3C to 2C acetyl. CO2 is released as a result). - Secondly, NAD+ is reduced to NADH